The challenge with the selection of a microcontroller for a project is: which one has the required number of UART, I2C, SPI? Combine this with the desired package (48pins, 64pins? LQFN?), the needed FLASH and RAM size and then even the hundreds of available microcontroller shrink to a handful only. And many times I need to make compromises: such as I need two hardware I2C, but the microcontroller matching all my other needs has only one I2C hardware. So I might end up with bit-banging the slower I2C bus. Doable, but not ideal.
What is cool that some of the newer NXP Kinetis microcontroller come with an interesting hardware: FlexIO. A peripheral hardware which allows me to implement a custom protocol, including driving WS2812B (Adafruit NeoPixel) LEDs with a FRDM-KL43Z board: